U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Differentiated thyroid carcinoma

MedGen UID:
277876
•Concept ID:
C1337013
•
Neoplastic Process
Synonyms: Differentiated thyroid cancer; Differentiated Thyroid Cancer; differentiated thyroid cancer; Differentiated Thyroid Carcinoma; differentiated thyroid carcinoma; differentiated thyroid gland cancer; Differentiated Thyroid Gland Carcinoma; differentiated thyroid gland carcinoma; DTC - differentiated thyroid cancer; Follicular/Papillary Thyroid Gland Carcinoma; Papillary or follicular thyroid carcinoma; papillary or follicular thyroid carcinoma; Thyroid Gland Differentiated Carcinoma; thyroid gland differentiated carcinoma; Thyroid Gland Well Differentiated Carcinoma; thyroid gland well differentiated carcinoma; Well Differentiated Thyroid Carcinoma; well differentiated thyroid carcinoma; Well Differentiated Thyroid Gland Carcinoma; well differentiated thyroid gland carcinoma; Well-Differentiated Thyroid Cancer; well-differentiated thyroid cancer; Well-differentiated thyroid carcinoma; well-differentiated thyroid carcinoma
SNOMED CT: DTC - differentiated thyroid cancer (1255086008); Differentiated thyroid cancer (1255086008); Differentiated thyroid carcinoma (1255086008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015447
Orphanet: ORPHA146

Definition

A rare, slow-growing, epithelial thyroid carcinoma typically presenting as an asymptomatic thyroid mass and is classed as either papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) or Hurthle cell thyroid cancer (HCTC). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDifferentiated thyroid carcinoma

Professional guidelines

PubMed

Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Haddad RI, Bischoff L, Ball D, Bernet V, Blomain E, Busaidy NL, Campbell M, Dickson P, Duh QY, Ehya H, Goldner WS, Guo T, Haymart M, Holt S, Hunt JP, Iagaru A, Kandeel F, Lamonica DM, Mandel S, Markovina S, McIver B, Raeburn CD, Rezaee R, Ridge JA, Roth MY, Scheri RP, Shah JP, Sipos JA, Sippel R, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Yeh M, Cassara CJ, Darlow S
J Natl Compr Canc Netw 2022 Aug;20(8):925-951. doi: 10.6004/jnccn.2022.0040. PMID: 35948029
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Laboratory Testing in Thyroid Conditions - Pitfalls and Clinical Utility.
Soh SB, Aw TC
Ann Lab Med 2019 Jan;39(1):3-14. doi: 10.3343/alm.2019.39.1.3. PMID: 30215224Free PMC Article

Recent clinical studies

Etiology

Update on iodine-refractory differentiated thyroid carcinoma.
Abou Jokh Casas E, Repetto A, Rodriguez Gasén A, Vercher Conejero JL, Bello Arques P, Cambil Molina T, Vallejo Casas JA
Rev Esp Med Nucl Imagen Mol (Engl Ed) 2023 Sep-Oct;42(5):325-334. Epub 2023 Jul 11 doi: 10.1016/j.remnie.2023.07.003. PMID: 37442524
Differentiated thyroid carcinoma: An update.
Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Treatment of Aggressive Thyroid Cancer.
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300
Recurrent well-differentiated thyroid carcinoma.
Magarey MJ, Freeman JL
Oral Oncol 2013 Jul;49(7):689-94. Epub 2013 Apr 25 doi: 10.1016/j.oraloncology.2013.03.434. PMID: 23623403

Diagnosis

Differentiated thyroid carcinoma: An update.
Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Small-Cell Malignancies of Thyroid: Challenge Solved?
Canberk S, Thodou E, Bongiovanni M
Acta Cytol 2022;66(4):307-318. Epub 2022 Jan 11 doi: 10.1159/000520876. PMID: 35016187
Thyroid Nodule/Differentiated Thyroid Carcinoma in the Pediatric Population.
Crockett DJ, Faucett EA, Gnagi SH
Pediatr Ann 2021 Jul;50(7):e282-e285. Epub 2021 Jul 1 doi: 10.3928/19382359-20210621-01. PMID: 34264794
Thyroid pathology: Controversies and best practices.
Nishino M
Semin Diagn Pathol 2020 Sep;37(5):211-212. Epub 2020 Aug 5 doi: 10.1053/j.semdp.2020.07.004. PMID: 32782166
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274

Therapy

Update on iodine-refractory differentiated thyroid carcinoma.
Abou Jokh Casas E, Repetto A, Rodriguez Gasén A, Vercher Conejero JL, Bello Arques P, Cambil Molina T, Vallejo Casas JA
Rev Esp Med Nucl Imagen Mol (Engl Ed) 2023 Sep-Oct;42(5):325-334. Epub 2023 Jul 11 doi: 10.1016/j.remnie.2023.07.003. PMID: 37442524
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
The central role of a two-way positive feedback pathway in molecular targeted therapies-mediated pyroptosis in anaplastic thyroid cancer.
Zhao Q, Feng H, Yang Z, Liang J, Jin Z, Chen L, Zhan L, Xuan M, Yan J, Kuang J, Cheng X, Zhao R, Qiu W
Clin Transl Med 2022 Feb;12(2):e727. doi: 10.1002/ctm2.727. PMID: 35184413Free PMC Article
Treatment of Aggressive Thyroid Cancer.
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300
Thyroid hormone therapy in differentiated thyroid cancer.
Grani G, Ramundo V, Verrienti A, Sponziello M, Durante C
Endocrine 2019 Oct;66(1):43-50. Epub 2019 Oct 15 doi: 10.1007/s12020-019-02051-3. PMID: 31617165

Prognosis

Differentiated Thyroid Carcinoma Long-Term Prognostic Factors.
Luis PO, Lucía MA, Hugo RC, Ramiro RM, Stalin CQ
Int J Surg Oncol 2024;2024:1067447. Epub 2024 Sep 10 doi: 10.1155/2024/1067447. PMID: 39291250Free PMC Article
Incidence and Clinicopathological Features of Differentiated High-Grade Thyroid Carcinomas: An Institutional Experience.
Jeong SI, Kim W, Yu HW, Choi JY, Ahn CH, Moon JH, Choi SI, Cha W, Jeong WJ, Park SY, Na HY
Endocr Pathol 2023 Sep;34(3):287-297. Epub 2023 Jul 29 doi: 10.1007/s12022-023-09778-w. PMID: 37515661
Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma.
Dierks C, Seufert J, Aumann K, Ruf J, Klein C, Kiefer S, Rassner M, Boerries M, Zielke A, la Rosee P, Meyer PT, Kroiss M, Weißenberger C, Schumacher T, Metzger P, Weiss H, Smaxwil C, Laubner K, Duyster J, von Bubnoff N, Miething C, Thomusch O
Thyroid 2021 Jul;31(7):1076-1085. Epub 2021 Apr 15 doi: 10.1089/thy.2020.0322. PMID: 33509020Free PMC Article
Lobectomy in patients with differentiated thyroid cancer: indications and follow-up.
Park JH, Yoon JH
Endocr Relat Cancer 2019 Jul;26(7):R381-R393. doi: 10.1530/ERC-19-0085. PMID: 31018176
Recurrent well-differentiated thyroid carcinoma.
Magarey MJ, Freeman JL
Oral Oncol 2013 Jul;49(7):689-94. Epub 2013 Apr 25 doi: 10.1016/j.oraloncology.2013.03.434. PMID: 23623403

Clinical prediction guides

TERT promoter mutations in thyroid cancer.
Matsuse M, Mitsutake N
Endocr J 2023 Nov 28;70(11):1035-1049. Epub 2023 Aug 1 doi: 10.1507/endocrj.EJ23-0136. PMID: 37532521
Skeletal health in patients with differentiated thyroid carcinoma.
Cellini M, Rotondi M, Tanda ML, Piantanida E, Chiovato L, Beck-Peccoz P, Lania A, Mazziotti G
J Endocrinol Invest 2021 Mar;44(3):431-442. Epub 2020 Jul 21 doi: 10.1007/s40618-020-01359-6. PMID: 32696339
Epigenetic modifications in poorly differentiated and anaplastic thyroid cancer.
Sasanakietkul T, Murtha TD, Javid M, Korah R, Carling T
Mol Cell Endocrinol 2018 Jul 5;469:23-37. Epub 2017 May 25 doi: 10.1016/j.mce.2017.05.022. PMID: 28552796
Poorly differentiated thyroid carcinoma: A hospital-based clinicopathological study and review of literature.
Win TT, Othman NH, Mohamad I
Indian J Pathol Microbiol 2017 Apr-Jun;60(2):167-171. doi: 10.4103/IJPM.IJPM_457_16. PMID: 28631629
Recurrent well-differentiated thyroid carcinoma.
Magarey MJ, Freeman JL
Oral Oncol 2013 Jul;49(7):689-94. Epub 2013 Apr 25 doi: 10.1016/j.oraloncology.2013.03.434. PMID: 23623403

Recent systematic reviews

Prevalence of Differentiated High-Grade Thyroid Carcinoma Among Well-Differentiated Tumors: A Systematic Review and Meta-Analysis.
Poma AM, Macerola E, Ghossein RA, Tallini G, Basolo F
Thyroid 2024 Mar;34(3):314-323. doi: 10.1089/thy.2023.0350. PMID: 38115626Free PMC Article
Radioactive Iodine in Differentiated Thyroid Carcinoma: A Systematic AGREE II Clinical Practice Guideline Appraisal.
Monos S, Fritz C, Harris J, Romeo D, Ng JJ, Xu K, Cooperberg B, Moreira A, Rajasekaran K
Otolaryngol Head Neck Surg 2024 Jan;170(1):20-33. Epub 2023 Sep 11 doi: 10.1002/ohn.508. PMID: 37694597
Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis.
Russo E, Guizzardi M, Canali L, Gaino F, Costantino A, Mazziotti G, Lania A, Uccella S, Di Tommaso L, Ferreli F, Malvezzi L, Spriano G, Mercante G
Rev Endocr Metab Disord 2023 Dec;24(6):1205-1216. Epub 2023 Oct 13 doi: 10.1007/s11154-023-09845-x. PMID: 37828383
Incidence, Recurrence and Mortality Among Filipinos With Differentiated Thyroid Cancer: A Systematic Review.
San Juan MD, Paz-Pacheco E
J ASEAN Fed Endocr Soc 2023;38(1):100-107. Epub 2023 Mar 2 doi: 10.15605/jafes.038.01.14. PMID: 37252408Free PMC Article
External beam radiotherapy in differentiated thyroid carcinoma: A systematic review.
Fussey JM, Crunkhorn R, Tedla M, Weickert MO, Mehanna H
Head Neck 2016 Apr;38 Suppl 1:E2297-305. Epub 2015 Sep 3 doi: 10.1002/hed.24218. PMID: 26335228

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...